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one can predict whether the child will overcome it

BASIC

  • Two-thirds of children with peanut allergy remain allergic until age 10. The remaining third who outgrow the allergy naturally do so between the ages of 4 and 6.
  • Researchers have found that by examining changes in the levels of two antibodies over several years, it is possible to predict whether a child will outgrow the allergy as an adult.
  • These biomarkers could improve care for peanut-allergic children.

Researchers at the Murdoch Children’s Research Institute (MCRI; Australia) have shown that a third of children with peanut allergies outgrow it naturally during adolescence. In addition, they found that analyzing changes in antibody levels over the years could predict which children were likely to have their allergies resolve without desensitization.

Their work was the subject of an article in the May 2024 issue of the magazine Allergy.

Peanut allergy: Antibody levels can predict its resolution

The study included 156 children from Melbourne with a confirmed peanut allergy. They were followed at ages four, six and 10 using questionnaires, skin tests, blood tests and dietary tests. A third of these young participants were no longer allergic by the age of 10. In general, their hypersensitivity reactions disappeared between 4 and 6 years of age.

Based on the data collected, the team noticed that changes in the levels of two antibodies that react to peanut allergens (called sIgG 4 and sIgE) were detected in children whose allergy resolved naturally. “Antibody levels measured at diagnosis did not predict who would outgrow peanut allergy, but changes in these levels over time revealed who was most likely to do so.”the scientists specify in the press release.

Thus, young patients who had decreasing blood levels of these two antibodies were more likely to no longer suffer from peanut allergy when they grew up. On the other hand, children who had high or increasing rates had an increased risk of still being allergic at age 10.

“Prior to this research, little was known about the possibility of using antibodies as biomarkers of natural resolution of peanut allergy during the elementary school years,” explains MCRI researcher Kayla Parker, who found that longitudinal changes were more useful in predicting children’s path to resolution of peanut allergy. rather than relying on a single frame at a single moment.”




Food allergy: a discovery that could improve care

According to Australian researchers, controlling the levels of antibodies in the blood would improve the care of young patients suffering from this potentially very dangerous food allergy within a few years.

“Children with peanut allergies whose antibody markers are declining may benefit from additional visits with their allergist to determine the right time to monitor their diet to confirm whether their peanut allergy is resolved,” says Kayla Parker. that they spontaneously overcome peanut allergy and could be prioritized for possible early treatment options if available.”

















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